Irunin inhengo inofungidza. Ichi chigadziro chakakura, izvo zvinobva pane triazole. Pfungwa ye Irunin (pamwe chete nemafananidzi ayo akafanana), inobva pakudzivisa kushandiswa kwe ergosterol muyero membrane yezvirwere. Iyo mishonga inoshanda zvakanyatsobudirira, asi nhamo, nekuda kwezvikonzero zvakasiyana, havasi vose vanogona kuitora.
Ndezvipi zvikonzero zvekufananidzira kweIrunin?
Chirwere ichi chinoshandiswa kurwisana nemhando dzakasiyana-siyana dzefungi: dermatophytes, mbiriso, zvinogadzirwa. Irunin ine yakakosha bioavailability. Chirwere ichi chinokurumidza kuwedzera mumuviri, uye maererano, uye chiito chinotanga nokukurumidza.
Ipai Irunin mufananidzo wekasiyo uye mapiritsi emadzimai ane matambudziko akadai se:
- fungal keratitis;
- dermatomycosis ;
- onychomycosis;
- pityriasis lichen ;
- histoplasmosis;
- sporotrichosis;
- systemic mycosis;
- blastomycosis;
- cryptococcosis;
- vulvovaginal candidiasis;
- systemic aspergillosis;
- Candidomycosis;
- paracoccidiomycosis;
- candidiasis.
Asi, kufanana nemafuta kana mahwendefa, Irunin inopesana nechekushanda:
- Mishonga haifaniri kutarisirwa kune avo varwere vanotambura nekusawirirana kwevamwe kune zvikamu zvehutano.
- Hazvina kunaka kutora mapiritsi kune vakadzi vane pamuviri. Irunin inosarudza vanaamai mune ramangwana chete mumatambudziko akasiyana, apo zvinotarisirwa zvikomborero zvichaita kuti zviitike.
- Hazvikurudzirwi kunwa mahwendefa neTerfenadine, Lovastine, Pimozil, Simvastin.
Chii chinogona kutora Irunin?
Kufanana nemutemo wekuita kwemishonga yakawanda. Nhamba yemhando dzakasiyana dzinosanganisira:
- Orugnal;
- Itraconazole;
- Canditral;
- Itramikol;
- Orunite;
- Rumikoz;
- Tecnazol;
- Orungamine;
- Miconiol.
Kutenga zvinodhaka, unofunga kufunga kuti dzakawanda zvekufananidza kweIrunin hazvina kudhura.