Chirwere cheNeurological of migraine , icho chinoratidzwa nezvisungo zvepfungwa dzakasimba uye zvinorwadza, zvakajairika nhasi. Mukurapa kwemigraine, kugadzirira kwemapoka akasiyana-siyana kunoshandiswa, uye mishonga pachayo inotarisirwa kuti zvose zvigadzirise migraine kurwisa uye kudzivirira ivo (kudzivirira). Kusarudzwa kwezvinodhaka zvinoshandiswa kune varwere vari voga, vachifunga nezvekuvhiringidza zvinhu, manzwiro-maitiro evanhu, kuvapo kwehutano hwakanaka, hukuru hwekutambudzika, nezvimwewo.
Imwe yemishonga inobatsira zvikuru yekubvisa zviratidzo zvemigraine ndiyo kugadzirira kweboka re triptans. Triptans inotungamirirwa nezvinodhaka izvo zvinongobatsira kubvisa zvinorwadza uye zvinowedzera migraine zviratidzo, asiwo kuderedza kuwanda kwekugumburwa.
Mechanism of action of triptans
Triptans mishonga yemigraine, iyo inokurudzirwa kune varwere vane mhirizhonga yakaoma (kurwiswa), pamwe chete nechirevo chechimiro chekushaya tsvina. Triptans ndezvinyorwa zve serotonin, murevereri wenheyo yenheyo.
Nzira chaiyo uye yakakwana yekuita kwezvinodhaka zveboka iri hazvina kunyatsodzidza kusvika ikozvino. Zvinofungidzirwa kuti iyi mishonga inorwisa migraine kurwisa, ine zvinotevera zvinokonzerwa ne trigeminovascular system (neurons ye-trigeminal nerve core uye midziyo isina kuvharwa yezviyo, iyo inobatanidzwa inokosha mu "kutanga" kwekurwisa):
- kudzivisa kwe trigeminal nerve system (neuroinhibitory effect);
- zvishoma nezvishoma midziyo ye cerebrospinal nemidziyo ye membrane yeuropi nekuderedza ropa mukati mavo (vasoconstrictor action).
Zvinofanira kuonekwa kuti triptans haipindi dzimwe mitsipa yeropa yemuviri womunhu.
Mhando dze triptans
Iko triptan yekutanga, iyo yakatanga kushandiswa kwemigraine, is sumatriptan. Kushandiswa kwechirongwa ichi, chidzidzo chavo, kliniki yekuedzwa yakabvumira kuvandudza migumisiro ye triptans uye kugadzira mishonga mitsva, inobudirira. Kusvika iye zvino, mishonga inonyanya kuzivikanwa uye yakashandiswa zvikuru kubva muboka re triptans ndeiyi:
- Naratriptan;
- Frovatriptan;
- Eletriptan;
- Risotriptan;
- Zolmitriptan;
- Almotriptan nevamwe.
Sezvo mutemo, triptans inowanikwa mune mahwendefa ekutaurira mumuromo. Zvisinei, panewo mazano okugadzirira iyi boka re intranasal (sprays) uye subcutaneous injections (injections), uyewo triptans nenzira ye rectal suppositories.
Zvinyorwa zve triptans
Tryptans inofanira kutorwa pakarepo mushure mokutanga kwekutanga kwezviratidzo zvekurwiswa kwemasimba. Matafura haagoni kunyowa, anoda kushambidzwa nemvura yakawanda. Sezvo mutemo, rimwe piritsi rinokwana kumira kurwisa. Kana marwadzo asingatauri, mapiritsi anotevera anogona kutorwa mushure memaawa maviri. Simbisai kushanda kwekushandiswa kwezvinodhaka zvemukirasi pamwe ne-non-steroidal anti-inflammatory drugs (pane zvinoratidzwa nachiremba).
Usatora triptans panguva ye migraine aura . Nekushungurudzika kwakakomba uye kurutsira, maitiro erectal, intranasal kana maitiro ekugadzirisa anosarudzwa. Tryptans haigone kutorwa kakawanda kanopfuura kaviri pavhiki. Iwe haugoni kusanganisa kushandiswa kwavo nemishonga inorwisa mabhakitiriya, zvinorambidza mishonga kana zvinodhaka.
Zvinotyisa sei triptans?
Zvidzidzo zvekuchipatara zvinoratidza kushivirira kwakanaka kwema triptans kuvarwere vakasiyana.
Triptans zvinopesana nezvakadaro:
- arterial hypertension;
- kusagadzikana kusingaperi kwemajeri ekupararira;
- heart failure;
- ischemic heart disease;
- zvakakomba zvakanyanyisa uye kusagadzikana kwechikadzi;
- pamuviri uye lactation.