Kuti varwise zvirwere zvezvirwere zvinokonzera fungal, mishonga yakawanda inogadzirwa nhasi. Uye pamberi pechiremba wega wega kune chisarudzo chakaoma chemishonga yakanakisisa mune iyi kana iyo iyo.
Matafura eK ketoconazole kana mamwe magadzirira anobva mazviri antifungal maitiro emabasa akawanda. Vanobatsira kurapa maitiro e-systemic, kureva, zvirwere zvinokonzerwa nefungi, pamwe chete nehutachiona hwehutachiona hwemafungidzi - mycoses, seborrhea.
Ketoconazole ine zvinokuvadza pambeu-kufanana nefungi yejeri Candida, dermatophytes, mold fungus, zvirwere zvakasiyana-siyana zvemasikirwe e systemic uye kunyange staphylococci uye streptococci.
Ndepapi mahwendefa eKetoconazole anorayirwa?
Zviratidzo zvekushandisa ketoconazole ndezvi:
- fungal zvirwere zvekudya gumbo;
- fungal zvirwere zvemuviri-urudzi, kusanganisira vaginini candidiasis, inonyatsozivikanwa se thrush, uyewo musikana asingagumi candidiasis;
- mycosis yezvipikiri, ganda, bvudzi, paronychia, folliculitis;
- seborrheic dermatitis (dandruff);
- fungal septicemia;
- mycosis eye;
- systemic mycoses - candidiasis, blastomycosis, histoplasmosis, etc ;;
- kudzivirira zvirwere zvinokonzera fungal kune vanhu vane immunodeficiency uye ngozi yakawanda yezvipembenene zvefungal.
Kana inotorwa nemuromo, kugadzirira mumapiritsi ne ketoconazole inopa mushonga unoshanda wepamusoro uye systemic mycoses. Chiito chechinhu ichi chinosanganiswa nekuparadzwa kwegadziriro ye biosynthesis ye ergosterol phospholipid uye triglycerides, iyo inobatanidzwa pakuumbwa kwefungal cell membrane. Pakupedzisira, kukura uye kuwedzera kwemasero aya anokuvadza kunoguma uye chirwere chacho chinoderera.
Kana inotorwa nemuromo, kugadzirirwa kwakanyatsokonzerwa, kureva, kunopindira muropa, zvakaparadzirwa mukati memaviri, chikamu chiduku chinopinda mukati mecherebrospinal fluid. Mushure mekunyora mumugwagwa wezvokudya, chinhu chinoshanda chinoshandiswa muropa chiropa, zvichiita nhamba yakawanda yekusagadzikana kwemasabolites. Mishonga iyi yakanyanyiswa mumuguta (13%), yakanyunyiswa ne bile uye yakanyongedzwa nemasese (57%).
Kazhinji mapiritsi 1-2 anotorwa zuva nechingwa kwevhiki mbiri, zvichienderana nechirwere uye uremu hwemuviri. Mushonga unogona kupiwa kune vana vanopfuura makore gumi nemaviri.
Contraindications nemigumisiro yekutora Ketoconazole
Matafura eKetoconazole kubva kune seborrheic dermatitis nezvimwe zvirwere zvefungal etymology zvinopesana mumakumbo, kuyamwisa, vana vane makore pasi pemakore gumi nemaviri, vanhu vane hypersensitivity ketoconazole uye nehutachiona hwakakomba hwepvo uye chiropa chinoshanda.
Iyo migumisiro yemigumisiro yekutora mahwendefa ndeyotevera:
- kushungurudza uye kurutsa;
- diarrhea;
- kurara chirwere;
- dhimoni, musoro;
- kurasikirwa kwebvudzi;
- paresthesia;
- exanthema;
- kuderedza chido chepabonde;
- gynecomastia;
- urticaria, kupisa kweganda;
- photophobia;
- fever.
Kurairwa kwemuromo kwekugadzirira kubva pa ketoconazole kunofanirwa kuendeswa nekuongororwa kwechiremba nguva dzose: kuongororwa kweropa, kutarisa kwechiropa uye mafungiro mabasa. Zvinonyatsopesana nezvinozvitsvaga uye kuzvipira nemishonga iyi. Mishonga inogona kurongerwa chete nechiremba.
Mune fungal meningitis, kushandiswa kwe ketoconazole hakunzwisisiki, sezvo chinhu chacho chisingapindi zvakanaka kuburikidza neBBB (hemato-encephalic barrier).
Kugadzirira kunobva pazvinhu izvi ndeye hepatotoxic, saka nzira inofanira kungoshandiswa apo inogona kubatsirwa inogona kuisa njodzi. Kunyanya inoshushikana nevarwere avo vanotambura nekunyanyisa kwekuita mabasa emakemikari ehepatic kana kuti vane utachiona hunokonzera chiropa nekuda kwekutora mamwe mishonga.
Kugadzirira ne ketoconazole mu mahwendefa
Heino mazita eanorogs anogs of ketoconazole mu mahwendefa (zvichienderana neshoko rinoshanda):
- Mycosorrhal;
- Fungistab;
- Dermazol;
- Oronazole;
- Nizoral ;
- KetoconazoleAltapharm;
- Ketoconazole DS;
- Mikanisal;
- Livarol;
- Mikoket;
- Fungin.