17-OH-progesterone (17-hydroxyprogesterone, 17-OGG, 17-oh-progesterone) ndiyo inotangira mahomoni; rudzi rwe "semi-finished product", iyo mahomoni akasiyana-siyana (cortisol, estradiol, testosterone) inoumbwa muhutano hwakaoma hwekuchinja kwemagetsi.
Zvikonzero zvinowedzera 17-OH-progesterone
Chikonzero chekuwedzera kwezinga re 17-oh-progesterone inowanzowanikwa muzvinyorwa zvinonzi adrenal kana mavari. Congenital adrenal cortex dysfunction (PDCN) ndicho chinonyanya kukonzera kukwidza kwakadaro. Kuwedzera kwekushaya muviri kunobatanidza nekushayikwa kana kusakosha kwe 21-hydroxylase enzyme, iyo, pamwe ne-17-OH-progesterone, inobatanidzwa mukubatanidzwa kwehomoni cortisol. Iyo enzyme haisipo kana iripo mune zviduku, panguva ino sezvo inotenderera mahomoni 17-OH-progesterone inogadzirwa zvakakwana kusvika pakuwedzera kwechimiro.
Kune miviri miviri yeVDKN: classical uye isina-classical. Chikoro cheVDKN chinotsanangurwa mumazuva okutanga / mwedzi yehupenyu hwemwana kuburikidza nezviratidzo zvekunze zvechirwere chemhemherodhi. Kuti uongorore uwandu hweusvlassical yeVDKN, sekutonga, zvinongowanikwa chete mumwana wechidiki (kusanangana nechekuita: hirsutism, acne, acne, kusagadzikana kwekuenda kumwedzi) kana munguva yekuberekwa (apo vakadzi vanotarisana nematambudziko ekuberekwa uye kugona).
Mukuwedzera, kuongororwa kweropa pakusarudza huwandu hwe-17-OH-progesterone kunogona kuratidza kuwandisa kwemaitiro kana:
- polycystic ovary syndrome (PCOS);
- uyerogen-inogadzira matumbo emavhizha kana mazino adrenal;
- urwere kana chirwere cheItenko-Cushing;
- hypothalamic syndrome;
- hyperprolactinemia ;
- uye dzimwe zvirwere.
Maitiro ekusimudzira 17-OH-progesterone
Maitiro ehomoni dzepabonde, kunyanya avo vanotanga 17-OH-progesterone, inogona kusiyanisa mune dzakasiyana-siyana dzinoongorora ma laboratories. Muchiziviso ichi chinofanira kutungamirirwa neanoratidzwa zviratidzo zveimwe laboratori, inowanzoratidzwa mumigumisiro yekuongorora.
Vane chiremba vanachiremba vanowanzodavira kuti nhamba yakakwirira ye-17-OH-progesterone mumukadzi ane hutano asiri mimba hairevi kurapwa uye inenge yakasiyana-siyana. Muganhu wekuwedzera uku ndiko 5 nmol / L = 150 ng / dl = 1.5 ng / l.
Vakadzi vane pamuviri havaiti kuongororwa ropa kwe17-OH-progesterone, panguva yekuzvitakura, chiyero che-17-GPG chinowedzera, ichi ndicho chimiro chepanyama. Uye zvakanyanya hazvina zvazvinobatsira kuronga kurapwa pane imwe nzvimbo yakakwirira ye-17-OH-progesterone panguva yekuzvitakura. Izvo chete zvisiri izvo zviitiko zvechikoro cheVDKN.
Nzira yekuderedza sei 17-OH-progesterone?
Kana, zvichienderana nemigumisiro yechipimo, chiyero che-17-OH-progesterone chawedzerwa, zvinokosha zvikuru kunzwisisa zvinokonzera kukanganisa vasati vatanga kurapwa. "Kuporeswa" kurapwa, kunoshandiswa nhamba yakawanda yechiremba, kuvimba nemaitiro ekare ekurapwa, hakugadziri dambudziko racho, asi rinowedzera kuwedzera.
Saka, sei kuderedza huwandu hwe 17-OH-progesterone? Pasinei nokuti chii chakakonzera kuwedzera, mukadzi anorayirwa kushandiswa kwenguva refu kweCOC - pamwe chete nemishonga yekudzivirira pamuviri (Jess, Yarin, Diana-3 kana vamwe). Saka, kana mukadzi akaonekwa kuti ane PCOS, pamwe nekushanda kwemajoka adrenal yeCOC-therapy imwe musati mimba isati yagadzirirwa, inowanzowanana.
Kana kukonzera kwepamusoro-soro ye-17-OCG isiri yevasclassical VDKN, kuongorora kwakazara kwe endocrinologist uye genetics zvakakosha,
Yakakura 17-OH-progesterone muhuwandu hwezviitiko zvinotyisa kushaya simba. Dexamethasone, prednisolone kana imwe glucocorticosteroids inofanira kutorwa chete munyaya yeiyo isina kuonekwa yePCDCA uye inongopa chete kuti kubata hakuitiki kwegore rimwe chete, uye zvimwe zvinokonzera kukonzera kusununguka hazvibvumirwi.