Mishonga yemishonga Metformin ndeyeboka re hypoglycemic agents. Kupfuura makore makumi mashanu Metformin yakashandiswa mukurapa, kunyanya chirwere cheshuga cheshuga. Nhengo inoshandiswa yemishonga inobata zvinotevera pamuviri:
- kunoderedza kusanganiswa kwehuga muropa ;
- kunoderedza kudya;
- kusimbisa lipolysis - kuitika kwemafuta kunopisa.
Zviratidzo zvekushandiswa kweMetformin
Metformin inokonzerwa nezvirwere zvinotevera:
- chirwere cheshuga mellitus type 2, kusanganisira mumatambudziko anoendeswa nekuneta;
- Gestational chirwere cheshuga - chirwere chinosangana nechirwere chemakinhydrate metabolism pamusana pekuchinja kwehomoni mumadzimai ane pamuviri;
- syndrome ye polycystic ovari muvakadzi vane kupesana kwemaitiro ekuglucose.
Uyezve, Metformin inoshandiswa seprophylactic yemamiriro ezvinhu anotyisidzira kutanga kwechirwere cheshuga (prediabetes). Mumakore achangobva kupfuura, ruzivo rwave rwakabudiswa kuti mishonga ye hypoglycemic inoderedza basa rezvinoumba zvinokurudzira kukura kwezvirwere zvinouraya mumakumbo emamota uye matumire ane chirwere cheshuga. Izvi zvinotsigirwa neongororo dzakaitwa nevasayendisiti kubva kuYunivhesiti yeMichigan (USA) uye Seoul University (South Korea).
Contraindications kushandiswa kweMetformin
Pane huwandu hunopesana nekushandisa kweMetmorphine. Izvi zvinosanganisira:
- dambudziko risingakanganisi kune nhengo dzakabatanidzwa mumetabolism (chiropa, impso nemapapu);
- ketoacidosis - chirwere chinosangana nekuputsa kweka carbon metabolism pamusana pekushaya kukwana kushushikana kwekugadzira;
- myocardial infarction;
- laktatsidoz - chirwere, nekuda kwekuti muviri unounganidza huwandu hwelactic acid;
- mamiriro ezvinhu anokonzera kupera simba (nemhaka yehutachiona, kushushikana kwepanyama) nekuwana pazvokudya zve-calorie;
- hypersensitivity kune zvikamu zvechirwere.
Nekutarisira kwakanakisisa Metformin inoshandiswa mukurapa vakadzi vane pamuviri uye vanokanganisa, pamwe nevarwere vakwegura kupfuura makore makumi matanhatu.
Metformin mushonga wechirwere cheshuga mellitus
Mahwendefa eMetformin anofanira kutorwa mushure mekudya, muyero wemishonga unobva pakuti inonzi insulini inoshandiswa kurapa murwere kana kwete. Munyaya iyi, inopiwa:
- Kune vanhu vasingatori insulini, mahwendefa maviri (1 g) kaviri pazuva pazuva rekutanga 3, kubva pamwedzi wechina kusvikira pazuva rechigumi nemana-2 mapiritsi maviri katatu pazuva. Kutanga kubva pazuva rechigumi nemashanu, kuyerwa kunoderedzwa maererano nekurumbidza kwachiremba zvichienderana nehuwandu hweglucose muhutachiwana (urine neropa).
- Nekushandisa kumwechete kwe insulini muhuwandu hwemauniti makumi mana pazuva, mutezo weMetformin wakafanana, asi chirwere che insulini chinoderedzwa zvishoma nezvishoma zvina masero pazuva.
- Pamusero we insulini inopfuura makumi mana emasero pazuva, kusanganisira mune remapiritsi Metformin, zvinokosha kuderedza muwandu we insulin apo apo murwere
pasi pekutariswa kwechiremba nguva dzose, somuenzaniso, kana uchigara muchipatara.
Kunyanya Metformin kuwedzerwa kunogona kukonzera hyperglycemia - kuwedzera kwemazinga eglucose uye kunyange zvakanyanya kuoma-ku hyperglycemic coma pamwe nemigumisiro inouraya. Munyaya iyi, zvakakosha kugara uchitarisa huwandu hweglucose. Kuwedzera kwehuwandu hwayo chiratidzo chekuti kutora mishonga kunofanira kuvharwa kwemazuva anoverengeka uye kuchinjwa kune insulin.
Cherechedza chinyorwa! Kurapa chirwere cheshuga ne metformin pasina kushandiswa panguva imwe chete nemimwe mishonga kunogona kukonzera kushaya simba nekutsumwa . Ichi ndechokuti chinhu chinoshanda chinoderedza zvinyorwa zveglycogen. Kuti abvise mararamiro asina kunaka zvinorudzirwa kuita jekiseni ye insulini.