Kugadzirira kunogadziriswa kwekudzivirira kwehutachiona hwevanhu kunonzi immunosuppressors, rimwe zita rinoreva immunosuppressants. Iri boka remishonga, sekutonga, rinoshandiswa pakuvhiya kwechikwata chekugadzirwa kwemuviri.
Immunosuppressive drugs - classification
Mishonga iri kuongororwa yakakamurwa kuva mapoka akasiyana maererano nemigumisiro yadzo pahutachiona:
- kudzivisa zvachose kudzivirira mishonga yemishonga. Izvozvo zvinoshandisa zvinokonzera majekiseni ose emasero emumune, kudzivirira basa ravo;
- kusarudza immunosuppressants for specific purpose for specific types of immune cells. Vanoita zvisarudzo zvinopesana, semuenzaniso, autoimmunity kana kutapurika zvirongwa zvekuzvidzivirira;
- mishonga ine-anti-inflammatory effect, iyo inoshandiswa mumamiriro ekusawirirana kweuropi;
- zviratidzo zvinoratidzira. Ichi chikamu chinotarisirwa chete kuti kuderedze zviratidzo zvezvirwere zvinotapukira.
Natural immunosuppressants
Zviratidzo zvemasikirwo ezvirwere zvinonyanya kushandiswa mukurapa zvirwere zvekudzivirira uye zvirwere zvekenza, sezvo vane simba rakaipa mumuviri. Uyezve, mishonga yemasikirwo ine zvisingabatsiri nemigumisiro, utachiona hahupi hunoita chiropa uye hahupindirani nekudya.
Pamwoyo weunofunusuppressant yemasikirwo ezvokwadi ndewechipiri metabolites (microbial origin), pasi nepamusoro-soro, eukaryotes. Kazhinji inonzi Streptomyces inoshandiswa, nokuti inonyatsomiririra vamiririri avo vane zvigadziriswe zvinorwisa mabhakitiriya anopesana, asiwo antifuginal effects.
Immunosuppressive drugs
Pakati pezvirwere zvemumunosuppressor zvinodzivisa masero ose emusununguko uye kudzivirira kuumbwa kwe lymphocytes muropa, iyo inowanzoshandiswa ndeyikuti:
- Vero-Cyclosporin;
- Cycloral;
- Imuran;
- Azathioprine.
Kazhinji, mazita ekunyorwa kwezvirwere zvinoshandiswa mukurapa kwemakumbo ekenza mumazamu ekupedzisira uye mushure mekuvhiyiwa kwomuviri, kunyanya kana kukanganwa kwemavara kwemavara kwakatanga.
Kugadzirira nechisarudzo (kusarudza) chiito:
- Timodepressin;
- Tacrolimus;
- Cyclosporin A.
Aya immunosuppressors anenge asingadi kudzivisa kusagadzikana kwezvirwere, usapindira nekuumbwa kwemasero ekuchengetedza muzvirwere zvehutachiona kana zvehutachiona.
Kurwisa-kupisa simba uye kubvisa zvirwere zvinokonzera zvirwere , zviratidzo zvehutano hwemoto zvinopiwa nemishonga iyi:
- Methylprednisolone;
- Fluuocinonide;
- Clobetasol;
- Prednisolone;
- Hydrocortisone.
Zvakakosha kuziva kuti glucocorticosteroid kugadzirira zvirwere zvinokonzerwa nemigumisiro ine huwandu hwemigumisiro yakakomba, iyo inowanzowedzera mamiriro ezvinhu emurwere. Izvi zvinokonzerwa ne-steroid yavo yakabva: iyi mishonga inopindirana nekuumbwa kwemahomoni anodiwa echiropa neitsvo.