Zvirwere zvepachiviri kune thyroglobulin - ichi ndicho chikuru chekuonekwa kwezvirwere zvehutachiona zvemotokari, zvakadai seatrophic autoimmune thyroiditis, chirwere cheHashimoto, chinokonzera kushaya goiter, nezvimwewo.
Chii chinonzi thyroglobulin?
Chaizvoizvo, thyroglobulin i glycoprotein, iyo iri chikamu chemirasi ye follicles yejeremusi yeganda. Iyo inoita basa repropeptide muhutachiona hwehomoni yekemikari. Mumashoko akajeka, thyroglobulin inogona kuratidzika seprotini inowanikwa mukati me follicles yejeremia gland. Mune nzira yekuvhara mahomoni thyroglobulin mune zvishoma inowira muropa. Maererano nezvimwe, mushonga usingazivikanwi, zvikonzero, unogona kuva autoantigen, iyo muviri unotanga kubudisa zvirwere. Zvirwere, kushamwaridzana nemagadzirirwo e thyroglobulin, inotanga kutevedzera zvinoitwa nehomoni. Muchiitiko ichi, chirwere chetachiona chinotanga kugovera muviri nemhomoni muhuwandu hwakawanda, kukanganisa kushandiswa kwemagetsi uye basa remwoyo.
Zvirwere zvekare kune thyroglobulin zvakagadzirirwa chinangwa chekuongorora chirwere chetachiona. Saka, kuti vanogona sei kudzivirira thyroglobulin, vachivhiringidza hutachiona hwemakemoni e thyroid. Apo masimba anokonzera thyroglobulin akawedzerwa, anogona kukonzera chirwere chetroroid, hypothyroidism kana, pane kudaro, kunyanya kunokonzera gland uye kunokonzera kurwara kwayo ( hyperthyroidism ).
Zvirwere zvekare kune thyroglobulin - inowanzo
Mishonga inokonzera thyroglobulin inobatsira chero ipi zvayo yeU / ml mumakamuri kubva pa 0 kusvika ku18. Saka, zvinogona kugumiswa kuti ma antibodies kune thyroglobulin haaderedzwi.
Zvirwere zvepamuviri kune thyroglobulin pamusoro pezvisizvo zvinogona kuwanika kune vanhu vane utano hwakakwana. Munyaya iyi, muvarume vanorwisa mabhodhi kune thyroglobulin yakawedzerwa zvishoma pane zvishoma pane vakadzi, kunyanya vakadzi vekukwegura.
Nzira yekuziva huwandu hwezvirwere zvekare kune thyroglobulin?
Kuwanda kwezvirwere zvegciwane ku thyroglobulin mumuviri kunogadziriswa nekuongorora ropa kubva mune mutsara. Kuongorora uku kunopiwa kune rimwe boka revanhu, iro:
- varwere vane hypothyroidism (subclinical kana kuoneka) kuziva chikonzero chekuoneka kwayo;
- kuti aone chinokonzera kuwedzera kwehukuru hwehutano hwehutano;
- varwere vanowana interferon uye lithiamu zvinodhaka, amiodarone. Varwere vane ma antibodies kune thyroglobulin vari kuwedzerwa, mushure mekutora madhiragi aya anogonawo kuwana chirwere chetachiona;
- yakasvibiswa, kana amai vane zvirwere zvinopesana ne thyroglobulin pamusoro pekugara.
Nokuda kwekuongororwa kwezvirwere kune thyroglobulin zvinokwanisika kuongororai mabasa ehutachiona, kuratidza hutachiona hwechirwere chacho uye chirwere chekurapa, kuratidza zvirwere zvekuzvarwa.
Zvirwere zvekare kune thyroglobulin zviri pamusoro pezvakanaka
Kana ma antibodies ku thyroglobulin akawedzerwa, zvikonzero zvingave kuvapo kwezvirwere zvinotevera:
- subacute kana chronic thyroiditis (40-70% yevarwere), Hashimoto's thyroiditis (97% yevarwere);
- Chirwere chechirwere (51% yevarwere);
- idiopathic myxedema (95% varwere);
- hypothyroidism (70% yevarwere);
- diffuse toxic goiter (40% yevarwere);
- asina kutenderwa kujekesa thyroid follicular uye papillary carcinomas (nonmedullary carcinomas (15-30% yevarwere);
- dzimwe autoimmune pathologies, kusanganisira kuora ropa kunokonzera.
Mukuwedzera, kana zvirwere zvinopesana ne thyroglobulin zvichiwedzerwa zvishoma, izvi zvinogona kuratidza kuvapo kwechromosomal kusagadzikana, kunyanya, Down syndrome kana Turner syndrome.
Mukana wekudzikisa huwandu hwemagandamende kune thyroglobulin mumuviri nekutora mishonga inonyanya kuderera. Mukurapa kwemazuva ano, kana zvirwere zvinoshandiswa ku thyroglobulin zviri kuwedzerwa, kurapwa, kuitira kuti kuunza nhengo yavo mumuviri mune zvakasarudzwa haisi kugoverwa. Saka, kushandiswa kwehemosorption, plasmapheresis, corticosteroids, "immunomodulator" haina maturo uye, kunyange, ine ngozi. Kusarudzwa kwe-l-thyroxine hakusiwo kwakarurama. Chirwere chacho pachacho chinoratidzirwa kurapwa, kunokonzerwa nekuwedzera mumuviri wehutachiona hwemasikirini kune thyroglobulin. Chiyero chemishonga inorapa thyroglobulin inorayirwa chete nechinangwa chekutaura kana kuramba kuongororwa, uye nenzira ipi zvayo yekuongorora kubudirira kwemishonga. Mutauriri anotaura kuti vanoda kuwana mari kune murwere, saka chenjererai.