Bilirubin is bile pigment, iyo inogadziriswa chigadzirwa chekugadziriswa kwekare kare masero matsvuku eropa. Kazhinji, munhu mukuru ane hutano mu plasma yeropa ine zvishoma zviduku (3,4 - 22,2 μmol / l), uyewo imwe yemuviri uri muchimiro che urobilinogens (4 mg) zuva nezuva.
Inenge 96 muzana yebilirubin muropa inenge isiri iyo isina kukwana bilirubin, isingasviki mumvura uye inotyisa, nokuti inokwanisa kutora nyore nyore kuburikidza nesero membrane uye kuvhiringidza mabasa anokosha emasero. Zvasara 4% zvinoreva bilirubin yakananga, yakasanganiswa mumvura, yakasvibiswa neitsvo uye yakanyanyiswa mumuguta. Zvose bilirubin inyanzvi yehuwandu uye yakashata bilirubin.
Mune zvimwe zvirwere, zvinyorwa zvebilirubin muropa, uyezve mumuguta, zvinowedzera. Izvi zvinokonzera jaundice uye kusviba kwemuti.
Zvinokonzera kukwirira kwebilirubin muvanhu vakuru
Ngationgororei, nekuda kwezvikonzero zvipi zvinowanzoitwa bilirubin muhupenyu hwemunhu zvinogona kusimudzwa kana kuwedzerwa.
Zvikonzero zvekuwedzera zvakananga bilirubin
Nhamba yezviri pachena bilirubin muropa inowedzerwa nekuda kwekuputsa kwekubuda kwebi. Somugumisiro, bile inotumirwa kuropa, kwete mumudumbu. Zvikonzero zveizvi kakawanda zvinotevera zvinetso:
- hepatitis of viral etiology muhutomu (hepatitis A, B, ine infectious mononucleosis);
- hepatitis yebhakteria etiology (leptospirosis, brucellosis);
- chronic hepatitis;
- autoimmune hepatitis;
- medicamentous hepatitis (semagumisiro ehomoni, kwete-steroidal anti-inflammatory drugs, antitumor zvinodhaka uye anti-tuberculosis drugs);
- toxic hepatitis (chepfu ye fungal poisons, industrial industrial toxic substances);
- kenza ye gallbladder, chiropa kana pancreas;
- cholelithiasis;
- biliary cirrhosis;
- syndromes we Rotor, Dabin-Johnson.
Zvikonzero zvekuwedzera zvisina kuenzaniswa bilirubin
Kuwedzerwa kwezvakanyorwa zvisinganzwisisiki bilirubin zvinogona kusanganiswa nekuparadzwa kwakakurumidza kwemasero matsvuku eropa kana nekuvhiringidzwa mukugadziriswa kwechinhu chisingaoneki bilirubin. Zvakakodzera kuziva kuti, kubva indirect bilirubin mumvura haiparadzi, kunyange nekuwedzera kukuru muzinga rayo muropa, hapana mararamiro ekuongorora urini. Saka, zvikonzero izvi zvinogona kuva:
- Congenital hemolytic anemia (sickle cell, spherocytic, nesferocytic, thallasemia, Marciyafawa-Michele chirwere);
- yechipiri hemolytic anemia (inopesana ne rheumatoid arthritis, systemic lupus erythematosus, lymphocytic leukemia, lymphanganulmatosis, nezvimwewo);
- mishonga inokonzera hemolytic anemia (inosanganisira insulini, aspirin, levomycetin, levofloxacin, cephalosporins, nezvimwe);
- syndromes aLucy-Driskol, Gilbert, Kriegler-Nayyar;
- zvirwere zvinotapukira (malaria, typhoid, sepsis);
- toxic hemolytic anemia ( inonyangadza nemhowa inouraya, chepfu, tsvina yemadhipa, nyoka, inouraya newaini, mushonga, mhangura yemhangura, nezvimwewo).
Zvikonzero zvinowedzera bilirubin pakuzvitakura
Kuwedzera bilirubin kunowanzoonekwa mumadzimai ane pamuviri (jaundice pamuviri). Zvikonzero zveizvi zvakakamurwa kuva mapoka maviri:
- nemhaka yehutachiona hwehupombwe (kuora mafuta zvakanyanya kwechiropa, gestosis, kurutsa zvakanyanya, nezvimwewo);
- inokonzerwa nezvirwere zvakasiyana-siyana zvinokonzera (hepatitis, hemolytic anemia, nezvimwewo).
Zvikonzero zvinowedzera bilirubin mumuguta
Nhamba yakawanda yebilirubin mumurini inowanikwa mune zvirwere pamwe chete nekukuvara kwemasero emuropa
- hepatitis;
- chirwere chechiropa ;
- metastatic chiropa kukuvara;
- chiropa chinokuvadza, nezvimwewo.
Kurapa kwepamusoro yebilirubin
Kana zviongorori zvinoratidza kuti bilirubin muropa kana mumurini yakakwirira, mitemo yekurapa inobva pane zvinokonzera chirwere ichi. Kazhinji, nzira dzokurapa dzinosanganisira kushandisa mishonga uye kugadzirisa kudya.