Imwe yenzira chaiyo yekuongororwa inobvumira kutarisa kuchinja kwemuviri mumuviri uye kufungidzira kuti kukura kwehumwe zvirwere panguva yepakutanga ndeye chirwere chekuongorora ropa. Ichi chidzidzo chinoitwa kuti chiongorore mamiriro ezvinhu ese nhengo dzose uye zvirongwa, izvo izvo zvinoratidzira zviratidzo zvezvikamu zvakawanda zveropa zvinoongororwa. Chimwe chiratidzo chakadai chiyero chealanine aminotransferase (ALT). Funga kuti rudzi rwezvinhu chii, uye rudzi rwekusaremara runogona kuratidzirwa nehupamhi hweAlT hunoonekwa pakutsvakurudzwa kweropa rinouraya.
Chii chinonzi ALT mukuedzwa kweropa?
Alanine aminotransferase iine enzyme isingagumi yeboka rekufambisa uye chikamu cheaminotransferase. Iyo inobudiswa nemasero eropa - hepatocytes. ALT inowanikwa kunyanya muchiropa, asi imwe yeiyo enzyme inowanikwawo muitsvo, mwoyo muscle, pancreas uye skeletal muscle tissue. Chikamu chiduku che enzyme iyi inowanikwa muropa (nhamba yevakadzi iri kusvika 31 U / l).
Basa guru re alanine aminotransferase rinobatanidzwa nekushandurwa kweamino acids. Izvi zvinoshanda sechinhu chinokurudzira pakuendeswa kwemamwe molecules. Apo simba retimetabolism rinodengenyeka, kuperevedza kwemukati membrane inowedzera, iyo inotungamirira kukuparadzwa kwemasero uye kusunungurwa kwe enzyme mu serumumu.
Zvikonzero zvepamusoro yeAIDS ATL
Kana kuongorora kwezvinhu zvipenyu kunoratidza kuti ALT muropa yakakwirira, chikonzero chezvizvi kakawanda chiitiko chinokanganisa chiropa. Asiwo kukohwa kwechinhu ichi kunogona kuwedzera nekuda kwekudzivirira kwevamwe nhengo. Ngationei, pane zvipi chaizvo zvirwere uye kuti ingano yeAlt yakawanda sei inopfuura kudarika:
- A 20 kusvika kuzana katatu kuwedzera muAlT kunogona kuratidza kuti yakaoma hepatitis nekuda kwechirwere chetachiona kana chepfu. Muhutachiona hwehutachiona hwepatachipatara A, kuwedzera uku kunowanikwa anenge mavhiki maviri kusati kwave kuonekwa jaundice, uye mushure memasvondo matatu kumira kwayo kunowanikwa. Ne viral hepatitis B uye C, ALT inogona kukura zvisingazivikanwi, uye zvadaro kuderera kusvika kune tsika dzakanaka. Kuwedzerwa kwechiratidzo ichi kunogonawo kuonekwa nekuwedzera kwekugara kwenguva refu yehupatitis, asi munyaya iyi, kudarika kwechimiro kunoitika 3 kusvika ku5 nguva.
- Kana ALT ichiwedzerwa 2 - katatu, inogona kutaura pamusoro pevasiri vasiri mafuta ane chiropa chirwere (steatosis). Kuchinja kwehutano kusvika kuchikamu che steatohepatitis kunoenderana nekuwedzera kukuru muzinga reAlt, pamwe nekuwedzera kwehuwandu hwehuwandu uye huri pachena bilirubin.
- Kuwedzerwa kashanu muhuwandu hwealanine aminotransferase muropa inowanzowanikwa muchiropa che cirrhosis, iyo inobatanidza nehutano hwekugadzirisa masero ehepatic ane mavara anobatana.
- Dzimwe nguva kuwedzera kwehutano hwe enzyme iyi inowanikwa nehutachiona hwemastast. Muchiitiko ichi, chikuru chechionda, chikuru kukura kweAlt muropa. Zvisinei, ane tumarara yakakura, somuenzaniso, ne hepatocellular carcinoma, kukanganisa kubva kuAATL chaiyo hakusakoshi, iyo inowanzomatanidza kuongororwa.
- Kuwedzera kwe ALT kusvika 600 U / L kunoteverwa nekuderera kwakakosha chiratidzo chekunyanya kushandiswa kwe bile bile ducts.
Chinhu chiduku chiduku chechimiro chinogona kuonekwa apo:
- myocardial infarction;
- myocarditis;
- heart failure;
- pancreatitis yakaoma ;
- kushungurudza mamiriro;
- dorowa hepatitis;
- infectious mononucleosis;
- myositis;
- acute lymphoblastic leukemia;
- gestosis yakaoma mumadzimai ane pamuviri (II trimester), nezvimwewo.
Uyezve, kuwedzera kweAATL kunogona kunge kuri mugumisiro wekutora mishonga yakadai sa:
- cholestatics;
- mishonga yekudzivirira pamuviri;
- estrogens;
- nicotinic acid;
- sulfonamides nevamwe.