Chimwe chezvinyanya kuzivikanwa nehutachiona uye immunomodulating zvinodhaka, Interferon Alpha, chigadzirwa che genetic engineering. Inobva pane protein yakachena, iyo inonzi analogo yeprotein yeropa revanhu uye inonzi interferon. Inogona kuva yemhando dzakasiyana-siyana, asi kugadzirira kunobva pa interferon alfa protein kunoratidzwa nepamusoro-soro bioavailability.
Mhando yekusunungurwa Interferon Alpha
Pane nzira dzakawanda dzokushandisa mushonga uyu, saka kusunungurwa kwemhando dzakasiyana-siyana dzechirwere zvinoshandiswa pamasvomisitiri:
- Dhaka yakaoma inoshandiswa mujinga pamwe chete nemvura yakasvibiswa;
- Yakagadzirirwa kugadziriswa kwejojo;
- rectal suppositories;
- mafuta;
- madonhwe emvura;
- nasal spray ;
- madonhwe eziso;
- mupfu wakaoma wekugadzirwa kwemasonte uye maziso emeso.
Kushandiswa kweInterferon Alpha
Kurapa neInterferon Alpha kunowanikwa pamusana wemaitiro antiviral effect. Izvo zvakagara zvichitaurirwa kuti munhu anoumba hutachiona mumwe mumuviri haagoni kutapukirwa nemumwe rudzi rwehutachiona. Nekuiswa kwe interferon, masero ayo chirwere ichi chisina kupinda, chichiramba chisingaiti uye pakupedzisira chirwere chacho chinopera. Sezvo urongwa uhwu hwakafanirwa nemavhidhiyo emhando ipi zvayo, rutivi rweInterferon Alpha rwakawanda kwazvo:
- viral hepatitis chero ipi zvayo;
- conjunctivitis;
- manyowa uye ophthalmic zvirwere;
- SARS , chirwere;
- laryngeal papillomatosis;
- multiple myeloma;
- leukemia;
- Kaposi's sarcoma;
- lymphoma;
- carcinoma;
- hutachiona uye bhaktericidal-utachiona hwehutachiona hwemarudzi ose muvana.
Kusiyana nedzimwe mishonga yemishonga yemishonga inogadzirwa, interferon ine zvishoma zvinopesana. Inoshandiswa nekuchenjerera mumamiriro ezvinhu ezvinetso nezvikamu zvekudzivirira uye zvimwe zvirwere zvechiropa. Panguva yekuzvitakura uye lactation mishonga inotorwa zvakakwana maererano nezvakanyorwa nachiremba. Zvimwe zvinokonzerwa neEntferon Alpha hazvikwanisi kunzi zvinonakidza, asi hazvishamisi. Izvi ndezvi:
- chills;
- fever;
- nausea;
- kugona.
Zvakakoshawo kuziva kuti mishonga iyi haina kunyanya kusanganiswa nemamwe mishonga yemishonga nemishonga, saka iwe unofanira kubvunzurudza mushonga nezvekushandisa umwe neumwe wavo. Izvi zvingabatsira kudzivisa zvinetso zvakakomba. Icho chisingadikanwi kutora interferon pamwe chete nemagariro uye zvinodhaka zvemishonga.
Nzira yekugadzira Interferon Alpha muhupfu, inobva pane zvinangwa. Nhamba inodaidzwa yemishonga inofanirwa kuve yakanyungudutswa nemvura yakasvibiswa yejojo inenge yakawandisa 50 ml. Kana uchida madonhwe mumhino dzako, kana maziso, unogonawo kushandisa saline (sodium chloride) nekuda kwechinangwa ichi.
Donhwe reziso MaInferon Alpha nemamwe marudzi emishonga akagadzirira kushandiswa uye haadi kuti kuwedzerwa kwezvimwe zvikamu.
Analoges of Interferon Alpha
Kusvika iye zvino, pane dzakawanda zvinodhaka zvakabva pane dzakasiyana-siyana. Dzimwe dzadzo dzinobva kune dzimwe nyika, dzimwe dziya dzinobva mumhuri, asi chiyero chekubudirira kwemishonga iyi yose inenge yakafanana. Musiyano chete ndiwo huwandu hweprotini yekuchenesa uye, saka, mutengo. Heino urongwa hwemishonga inogona kutora Interferon Alpha:
- Alfarekin;
- Intron A;
- Roferon;
- Nasoferon;
- Vellveron;
- interferon leukocyte vanhu nevamwe.
Mishonga iyi yose yakagadzirirwa kuratidzira kuratidzwa kwemavhidhiyo akasiyana-siyana, kubvisa kupararira kwemuviri, kudzivirira utachiona hwemasero matsva, kusimbisa chikamu chemukati. Kutenda kuhutano hwemakemikari ehupi hunokosha, muviri unosimbisa masimba ehurumende uye inotanga kuzvimiririra kurwisa zvirwere. Uyewo kuburitsana kwemarudzi ose ane chinopesana, izvo zvinokonzera izvo zvisati zvave zvakanyatsogadziriswa kupedzana, zvisinei, kushandiswa kwemishonga yekurapa nekudzivirira kenza hakubvumirwi.