Clavulanic acid chinhu chakakosha chinosangana ne penicillinase uye hachiiti. Inogona kuonekwa mukugadzirwa kwemishonga yakawanda yakabatana. Mukuwedzera, clavulanic acid inogona kushandiswa zvakafanana ne beta-lactam antibiotics.
The mechanism of action of clavulanic acid
Nyanzvi dzinotaura kuti clavulanic acid kune metabolism. Ichi chinhu chinogona kubudisa simba rinorwisa maitiro antimicrobial. Mishonga iri ne clavulanic acid inoratidzirwa kuti ishandiswe mune zvirwere zvakasiyana-siyana zvinopisa zvinokonzerwa nehutachiona hweropa uye mabhakitiriya.
Chimiro chemamolekoro e clavulanic acid chakafanana nemishonga inorwisa mabhakitiriya emutsara we penicillin. Ndiko kusaka kusanganiswa kwavo kubva pakuonekwa kwepasimusi kunofungidzirwa kunyanya kubudirira. Mhedzisiro huru ndeyokuti mu acid asi panzvimbo ye thiazolidine kune ringin oxazolidine. Asi kuwirirana kwezvinhu hazvina kukanganiswa.
Kupinda mumuviri, clavulanic acid inhibits beta-lactamase - mabhakitiriya enzyme, maitiro ayo anoita kuti basa rinokosha rezvipembenene zvinokuvadza. Nenzira yakawanda, chirevo chechiito che clavulanic acid chiri nyore: kuburikidza nehombe yekudzivirira, inopinda mukati memasero eabhakitiriya uye "inodzima" ma enzymes ari mukati. Nokudaro, chinhu chacho hachibvumi kuti mavairasi uye mabhakitiriya awedzere.
Sezvo chiitiro chakaratidza, mushure mokuderedza, kuderedzwa kwe beta-lactamase kunofungidzirwa zvisingabviri. Nokuda kweiyi pathogenic microorganisms haigoni kukura, asiwo inorasikirwa nemukana wekudzivisa kushorwa nemishonga inorwisa mabhakitiriya inovadzvinyirira.
Kubudirira kwezvinhu izvi zvakanyanya kwazvo. Kunyange izvo zvipembenene zvebhakitiriya uye mavairusi akakwanisa kukudzivirira hutachiona hweAlexxicillin neAmpicillin zvinoparadzwa nechiito che clavulanic acid. Iko ndiko kuti, maitiro emabasa ekubatanidza madhiragi yakawanda kwazvo kupfuura aya evanhu vanorwisa mabhakitiriya.
Chaizvoizvo, zvinodhaka ne clavulinic acid zvinotorwa nemuromo, asi mune dzimwe nguva, maitiro avo ekutarisira anonzi anoshanda zvakanyanya. Sezvo zvakadaro, hapana hupikisano hwemugadziro, hahufadzi chete kune varwere vane kusagadzikana kwevanhu. Mune zviitiko zvakanyanya zvakaoma, clavulic acid pamwe chete naAmoxicillin uye Ticarcillin inogona kutorwa kunyange nevakadzi vane pamuviri.
Augmentin - Amoxicillin ane clavulanic acid
Ichi ndechimwe chezvinozivikanwa zvikuru zvinosanganiswa nemishonga inorwisa mabhakitiriya. Chirwere ichi chinoratidzwa nehutano hwakadaro:
- bronchitis (kusanganisira muhupenyu husingaperi);
- pneumonia;
- chikamu chemapapu ;
- mabhakitiriya zvirwere;
- cystitis;
- peritonitis;
- osteomyelitis;
- angina;
- septicemia;
- pyelonephritis.
Nhamba ye Augmentin yemurwere mumwe nomumwe yakasarudzwa pane mumwe nomumwe, zvichienderana nemafomu uye kuoma kwechirwere, mamiriro ezvinhu ehurwere, makore ake, kuongororwa kunoitwa. Mishonga pamwe nemishonga inofanira kupedzisira isiri pasi pemashanu, asi kwete mazuva gumi nemana.
Flemoxin ne clavulanic acid
Ichi chimwe chibatanidzwa chinozivikanwa, chinonzi Flemoklav. A good antibacterial agent inodhura zvishoma pane Flemoxin yepakutanga, asi mutengo wayo wakarurama zvakakwana nekubudirira kwayo.
Chishandiso chinoshandiswa kurapa maitiro akasiyana-siyana ekuputika:
- otitis media;
- pharyngitis ;
- bronchitis;
- ruzivo rwemagariro evanhu;
- gynecological infections;
- dermatological inflammations;
- zvipembenene zvinotapukira uye zvinoputira mapfupa nemajoini.
Flemoklav inosunungurwa nenzira yehwendefa yakasvibiswa, nemhaka yekuti kubudirira kwayo kunowedzera zvakanyanya.