Bacteriophages - Species uye chinangwa

Imwe chete nzira inoshanda yekushandiswa kwemishonga inorwisa mabhakitiriya kubva kumapakitiriya emaprogenic kusvika nhasi ndiwo mapeji kana bacteriophages. Izvo zvipembenene zvakajeka izvo zvinosarudza zvirwere zvakasiyana-siyana zvemakiromita. Mapoka mashoma anozivikanwa pakurapa, umo mabhakiteriophage akaparadzana - mhando uye chinangwa chezvipembenene izvi zvinoumba hwaro hwekugadziriswa kwemaitiro akawanda.

Chii chinonzi bacteriophages?

Iko kune mhuri 19 yemavirusi ari mubvunzo. Izvo zvakasiyana nemhando ye nucleic acid (RNA kana DNA), maitiro e genome uye fomu.

Mukurapa, bhakteriophage inorongwa maererano nehuwandu hwekuparadzwa kwebhakitiriya repathogenic:

1. Virulent. Utachiona, kupinda mumasero emakiromita, hunotanga kukurumidza uye kuwedzera, zvinowanzotungamirira kurufu rwebhakitiriya (lytic effect).
2. Moderate. Bacteriophages zvishoma nezvishoma uye zvinongoparadza zvishoma zvinyorwa zvepathogenic, asi zvinokonzera kusagadziriswa kuchinja mazviri, izvo zvinoendeswa kune zvizvarwa zvinotevera zve microbes (lysogenic effect).

Nhasi, iyo yakatsanangurwa mavara evhapirasi inoshandiswa seimwe nzira yemishonga inorwisa mabhakitiriya mukurapa kwehutachiona hwehutachiona hwakasiyana-siyana. Pakati pezvakanaka, zvakakosha kucherechedza zvinotevera:

1. Nzira yakanaka yekusunungurwa. Bacteriophages inobudiswa muhwendefa uye nenzira yegadziriro yekutaura kwemuromo.
2. Zvishomanana migumisiro. Kusiyana nemishonga inorwisa mabhakitiriya, bhakteriophages zvishoma zvishoma zvinokonzera zvirwere zvinoratidzika, hazviiti zvinokonzerwa nemigumisiro yechipiri pamuviri.
3. Kushaiwa kwema microbial resistance. Mabhakitiriya akaoma kuchinjwa mavairusi, uye zvinetso zvakaoma hazvigoneki.

Pane zvimwe zvisingabatsiri:

• nguva yakareba yekurapa (kusvika mazuva makumi maviri);
• matambudziko pamwe nekusarudzwa kweboka rakanaka remishonga;
• kutengesa bhakitiriya genome kubva kune imwe microbe kusvika kune imwe.

Marudzi eBacteriophages uye kushandiswa kwavo

Ichitaura nezvehutachiona hwehutachiona hunotsanangurwa, mukurapa, mabhakitiriro akawandisa uye akaoma akaine marudzi akasiyana-siyana emakiromita aya anosarudzwa.

Pano, chii chinonzi bacteriophages - rondedzero uye tsanangudzo:

1. Abdominal. Zvinokuvadza zvinokuvadza zvirwere zvehupidhi fever, salmonella.
2. Dysfag, dysentery yakawanda. Yakashandiswa kubhakitiriya maronda, inokonzera kufa kwaShigella Sonne naFlexner.
3. Klebsifag, Klebsiella pneumonia. Inobatsira mukurapa kwezvirwere zveUrogenital, kudya, kupemha, zvirwere zvinokonzerwa nehutachiona hwehutachiona, zvirwere zvekuvhiya zvinokonzerwa ne pneumonia klebsiella .
4. Klebsiellezny yakawanda. Iyo mishonga yakaoma inoparadza Klebsiella kwete chete pneumonia, asiwo rhinoscleromas, ozena.
5. Colitis, kana. Kubudirira mukurapa kwehupi hutachiona hwemukati nhengo neganda zvakakonzerwa naE E. coli enteropathogenic E. coli.
6. Coliproteophage, coliprotein. Iyo inokanganisa zvakanyanya mabhakitiriya e-enteropathogenic Proteus uye Escherichia. Icho chinotarisirwa kurapwa kwechirpitis, cystitis, colitis, pyelonephritis nedzimwe zvirwere zvinokonzerwa nemukati midzi uye prost.
7. Proteophagus, Protean. Zvinokonzera rufu rwehuwandu hweproteus microbes mirabilis uye vulgaris, izvo zvinokonzera kukanganisa kwe purulent kuporesa maitiro emutsipa.
8. Pseudomonas aeruginosa. Inoshandura mabhakitiriya pseudomonas aeruginosis. Inokurudzirwa kuti dysbiosis, pamwe chete nekurapa kwekuvhiringidza mumitemo yakasiyana-siyana yemitambo yakakonzerwa naPseudomonas aeruginosa.
9. Staphylophage, staphylococcus. Rinokurumidza kusabvisa staphylococci, iyo inosunungurwa semugumisiro wehupi hwehutachiona hwepurasitiki.
10. Streptophagus, streptococcal. Saizvozvowo mune nzira yekuita kune britteriophage yapfuura, asi iri kushanda pakurwisa streptococci.
11. Intersti. Izvo zvakagadziriswa kugadzirira lysing salmonella, shigella, E. coli , staphylococcus, enterococci, pseudomonas aeruginosa uye proteus.
12. Piopolyphage, pamwe chete piobacteriophage. Mhinduro iyi yakafanana nemhando dzakapfuura, asi inoshandawo kubva kune streptococci.
13. Sextapage, pyobacteriophagous polyvalent. Kuwedzerwa kunouraya escherichia coli.
14. Complex piobacteriophage. Musanganiswa wepa phagolysates ye-enterococci, streptococci, staphylococci, vulgaris uye mirabilis proteasis, klebsiella oxytoca uye pneumonia, escherichia coli, pseudomonas aeruginosis.